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KMID : 1007520130220000213
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Food Science and Biotechnology
2013 Volume.22 No. 0 p.213 ~ p.220
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Anti-inflammatory Effects of 4 Medicinal Plant Extracts in Lipopolysaccharide-induced RAW 264.7 Cells
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Jang Mi
Jeong Seung-Weon
Cho Somi-K
Ahn Kwang-Seok
Kim Bum-Keun
Kim Jong-Chan
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Abstract
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The anti-inflammatory activity of 4 plant extracts [guava (Psidium guajava) leaf, capillary wormwood (Artemisia capillaris Thunb.), Chinese goldthread (Coptis chinensis), and dandelion (Taraxacum platycarpum)] was investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Six phenolic compounds (gallic acid, caffeic acid, chlorogenic acid, catechin, quercetin, and baicalin) were analyzed using LC-MS/MS. Guava leaf extracts showed the highest inhibitory effects on LPS-induced nitric oxide (NO, 52.58%) and prostaglandin E2 (PGE2, 43.45%) production. The total phenolic contents (TPC) in guava leaf, capillary wormwood, Chinese goldthread, and dandelion were 426.84, 154.42, 41.73, and 122.04 mg of gallic acid equivalent (GAE)/g of extract, respectively. TPC was positively correlated with the NO-inhibitory effect (r= 0.963, p<0.05) and the PGE2-inhibitory effect (r=0.971, p<0.05) at 30 μg/mL of treatment. The guava leaf extracts contained the highest levels of gallic acid and catechin, while the capillary wormwood extracts contained the highest levels of chlorogenic acid and quercetin.
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KEYWORD
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Psidium guajava, Artemisia capillaris Thunb., Coptis chinensis, Taraxacum platycarpum, anti-inflammation
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